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Douglas Ruden, Ph.D. |
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Wayne State University |
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Tel. |
(313) 964-5251 |
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Fax. |
(313) 577-0082 |
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Email: |
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Address: |
Institute of Environmental Health Sciences
Wayne State University |
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| Research Interests: | ||
| Toxicogenomics of heavy metal exposure using Drosophila and mouse models. | ||
| Select Publications: | ||
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Ruden DM, Lu X and
Garfinkel MD. Methods for Nutrigenomics and Longevity
Studies in Drosophila: Effects of Diets High in Sucrose,
Palmitic Acid, Soy, or Beef. 2006 Methods in Molecular
Biology, in press. Ruden DM and Lu X. Evolutionary Conservation of Metabolism Explains How Drosophila Nutrigenomics Can Help Us Understand Human Nutrigenomics. 2006 Genes and Nutrition, in press. Keith SW, Redden DT, Katzmarzyk P, Boggiano MM, Hanlon EC, Benca RM, Ruden DM, Pietrobelli A, Barger J, Fontaine KR, Wang C, Aronne LJ, Wright S, Baskin M, Dhurandhar N, Lijoi MC, Grilo CM, DeLuca M, Westfall AO, and Allison DB. Putative Contributors to the Secular Increase in Obesity: Exploring the Roads Less Traveled. 2006 Int. J. Obes., in press. Xiao L, Lu X, and Ruden DM. Effectiveness of Hsp90 Inhibitors as Anti-Cancer Drugs. 2006 Mini Rev. in Medicinal Chem., in press. De Luca M, Yi N, Allison DB, Leips J, Ruden DM. Mapping quantitative trait loci affecting variation in Drosophila triacylglycerol storage. Obes Res. 2005 Sep;13(9):1596-605. PMID: 16222063 Ruden DM, De Luca M, Garfinkel MD, Bynum KL, Lu X. Drosophila nutrigenomics can provide clues to human gene-nutrient interactions. Annu Rev Nutr. 2005;25:499-522. PMID: 16011476 Ruden DM, Xiao L, Garfinkel MD, Lu X. Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer. Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R149-55. PMID: 15809267 Garfinkel MD, Sollars VE, Lu X, Ruden DM. Multigenerational selection and detection of altered histone acetylation and methylation patterns: toward a quantitative epigenetics in Drosophila. Methods Mol Biol. 2004;287:151-68. PMID: 15273410 Ruden DM, Garfinkel MD, Sollars VE, Lu X. Waddington's widget: Hsp90 and the inheritance of acquired characters. Semin Cell Dev Biol. 2003 Oct;14(5):301-10. PMID: 14986860 Gao Z, Joseph E, Ruden DM, Lu X. Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility. J Biol Chem. 2004 Apr 2;279(14):14225-31. Epub 2004 Jan 19. PMID: 14732716 Garfinkel MD, Ruden DM. Chromatin effects in nutrition, cancer, and obesity. Nutrition. 2004 Jan;20(1):56-62. PMID: 14698015 Gao Z, Ruden DM, Lu X. PKD2 cation channel is required for directional sperm movement and male fertility. Curr Biol. 2003 Dec 16;13(24):2175-8. PMID: 14680633
Hirsch HV, Mercer J,
Sambaziotis H, Huber M, Stark DT, Torno-Morley T, Hollocher
K, Ghiradella H, Ruden DM. Behavioral effects of chronic
exposure to low levels of lead in Drosophila melanogaster.
Neurotoxicology. 2003 Jun;24(3):435-42. PMID: 12782108 |
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