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Raymond Mattingly, Ph.D. |
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Wayne State University Associate Core Leader, Cell Signal and Function Research Core, EHS Center for Molecular & Cellular Toxicology |
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Tel. |
(313) 577-6022 |
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Fax. |
(313) 577-6739 |
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Email: |
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Address: |
Department of
Pharmacology |
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| Research Interests: | ||
| Integration of signal transduction through ras and heterotrimeric GTP- binding proteins; role of cell signaling in the control of cell growth, tumorigenesis, metastasis and the response to toxic insult. | ||
| Select Publications: | ||
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Menard RE, Jovanovski AP, Mattingly RR. Active
p21-Activated Kinase 1 Rescues MCF10A Breast Epithelial
Cells from Undergoing Anoikis. Neoplasia. 2005
Jul;7(7):638-45. PMID: 16026643
Yingst DR, Massey KJ, Rossi NF, Mohanty MJ, Mattingly
RR. Angiotensin II directly stimulates activity and
alters the phosphorylation of Na-K-ATPase in rat
proximal tubule with a rapid time course. Am J Physiol
Renal Physiol. 2004 Oct;287(4):F713-21. PMID: 15161602
Chopra DP, Menard RE, Januszewski J, Mattingly RR. TNF-alpha-mediated
apoptosis in normal human prostate epithelial cells and
tumor cell lines. Cancer Lett. 2004 Jan
20;203(2):145-54. PMID: 14732222
Menard RE, Mattingly RR. Gbetagamma subunits stimulate
p21-activated kinase 1 (PAK1) through activation of
PI3-kinase and Akt but act independently of
Rac1/Cdc42.FEBS Lett. 2004 Jan 2;556(1-3):187-92. PMID:
14706848
Menard RE, Mattingly RR. Cell surface receptors activate
p21-activated kinase 1 via multiple Ras and
PI3-kinase-dependent pathways. Cell Signal. 2003
Dec;15(12):1099-109. PMID: 14575865
Yang H, Cooley D, Legakis JE, Ge Q, Andrade R, Mattingly
RR. Phosphorylation of the Ras-GRF1 exchange factor at
Ser916/898 reveals activation of Ras signaling in the
cerebral cortex. J Biol Chem. 2003 Apr
11;278(15):13278-85. PMID: 12538592
Mattingly RR, Gibbs RA, Menard RE, Reiners JJ Jr. Potent
suppression of proliferation of a10 vascular smooth
muscle cells by combined treatment with lovastatin and
3-allylfarnesol, an inhibitor of protein
farnesyltransferase. J Pharmacol Exp Ther. 2002
Oct;303(1):74-81. PMID: 12235235
Keshamouni VG, Mattingly RR, Reddy KB. Mechanism of
17-beta-estradiol-induced Erk1/2 activation in breast
cancer cells. A role for HER2 AND PKC-delta. J Biol
Chem. 2002 Jun 21;277(25):22558-65. PMID: 11960991
Beqaj S, Jakkaraju S, Mattingly RR, Pan D, Schuger
L. High RhoA activity maintains the undifferentiated
mesenchymal cell phenotype,whereas RhoA down-regulation
by laminin-2 induces smooth muscle myogenesis. J Cell
Biol. 2002 Mar 4;156(5):893-903. Epub 2002 Mar 4. PMID:
11877460
Mattingly RR, Felczak A, Chen CC, McCabe MJ Jr,
Rosenspire AJ. Low concentrations of inorganic mercury
inhibit Ras activation during T cell receptor-mediated
signal transduction. Toxicol Appl Pharmacol. 2001 Nov
1;176(3):162-8. PMID: 11714248
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