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Hyesook Kim, Ph.D. |
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Wayne State University |
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Tel. |
(313) 961-1606 |
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Fax. |
(313) 577- 0082 |
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Email: |
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Address: |
Institute of Environmental Health Sciences
Wayne State University |
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| Research Interests: | ||
| Cytochrome P450 (CYP) 2C11, CYP2C23, CYP2B1, and CYP2B2 expressed in rats, CYP2C1 and CYP2C2 expressed in rabbits, and CYP2C8 and CYP2C9/2C10 expressed in human have been identified to be arachidonic acid (AA) epoxygenases. Recently, CYP2J, a novel CYP subfamily with AA epoxygenase activity, has been found in humans (CYP2J2), rats (CYP2J3) and rabbits (CYP2J1). Sprague-Dawley rats were treated with dexamethasone (DEX). DEX treatment dramatically decreased hepatic AA epoxygenase activity. DEX treatment decreased CYP2C23 levels but failed to affect CYP2B1, CYP2B2 or CYP2C11 levels. The results suggest that the decrease in AA epoxygenase activity after DEX treatment was a result of decreased CYP2C23 levels. Our laboratory will study effect of DEX on renal AA epoxygenases and soluble epoxide hydrolase. | ||
| Select Publications: | ||
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A. S. A. Gracon, S. J. Pernecky, M. C. Milletti, J.-A Park,
Y. Yuan and H. Kim (2005) Computational characterization of
a series of eicosanoids. Letters in Drug Design &
Discovery 2,239-244. H. Kim, D. A. Putt, R. C. Zangar, C. R. Wolf, F. P. Guengerich, R. J. Edwards, P. F. Hollenberg and R. F. Novak (2001) Differential induction of rat hepatic cytochromes P450 3A, 2B and 2E1 in response to pyridine treatment. Drug Metab. Dispos., 29, 353-360. Patent: "Detection of hypertension using immunoreactive metabolic products" US patent #6,440,682 and #6,534,282 (2 divisional patents issued on 8/27/02 & 3/18/2003, respectively), http://patft.uspto.gov/netahtml/srchnum.htm |
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