Publications:

1. Abdelmegeed MA, Carruthers NJ, Kim SK, Woodcroft KJ, and Novak RF (2005) Acetoacetate induces cytochrome P450 (CYP) 2E1 protein and suppresses CYP2E1 gene transcription in primary cultured rat hepatocytes. J Pharmacol Exp Ther. In Press.

2. Kim SK, Woodcroft KJ, Abdelmegeed MA, and Novak RF (2005) Role of Mechanical and Redox Stress in Activation of Mitogen Activated Protein Kinases in Primary Cultured Rat Hepatocytes. Biochem Pharamcol. In Press.

3. Abdelmegeed MA, Woodcroft KJ, Carruthers NJ, Khodadadeh SS, Kim SK, and Novak RF (2005) Epidermal Growth Factor Receptor, Phosphatidylinositol 3-Kinase and Akt Signaling Mediate EGF Suppression of CYP2E1 in Primary Cultured Rat Hepatocytes. In Preparation.

4. Kim SK, Woodcroft KJ, Abdelmegeed MA, and Novak RF (2005) Effects of PD98059 on GSH homeostasis in primary cultured rat hepatocytes. In Preparation.

5. Kim SK, Abdelmegeed MA, and Novak RF (2005) Insulin Signaling in Regulation of Alpha-Class Glutathione S-Transferase Expression in Primary Cultured Rat Hepatocytes.
In Preparation.
 

6. Abdelmegeed MA, Kim SK, Woodcroft KJ, and Novak RF (2004) Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress. J Pharmacol Exp Ther 310:728-736.

7. Abdelmegeed MA, Suh DH, and Abdelrahman MS (2001) Intra-Species Extrapolation in Risk Assessment of Different Classes of Antimicrobials. Human Ecol Risk Assess 7:15-36.

Abstracts:

1. Abdelmegeed MA, Carruthers NJ, Woodcroft KJ, Novak RF (2005) Acetoacetate Inhibits Cytochrome P450 (CYP) 2E1 mRNA Through Suppression of Transcription and Induces CYP2E1 Protein Through Increased Translation and Decreased Protein Degradation in Primary Cultured Rat Hepatocytes. FASEB J 19: A1568 - A1569.

2. McClung H, Abdelmegeed MA, and Novak RF (2005) Regulation of CYP2E1 by Ghrelin in Primary Cultured Rat Hepatocytes. FASEB J 19: A1569.
 

Presentations:

• Poster Presentation: “Acetoacetate inhibits cytochrome P450 (CYP) 2E1 mRNA through suppression of transcription and induces CYP2E1 protein through increased translation and decreased protein degradation in primary cultured rat hepatocytes”. ASBMB, San Diego, CA, 2005.

• Poster Presentation: “Activation of MAP kinase signaling pathways by acetoacetate in primary cultured rat hepatocytes”. ASBMB, San Diego, CA, 2003.

• Intra-species extrapolation in risk assessment of different classes of antimicrobials. The fourth annual workshop on evaluation of default safety factors in health risk assessment, Newark, NJ, 2000.

 

Academic Honors and Awards:

• “First” place recipient in the Best Paper Award Competition in the Student Category, Drug Metabolism Division of the American Society for Pharmacology &
Experimental Therapeutics, for the submission “Acetoacetate inhibits cytochrome P450 (CYP) 2E1 mRNA through suppression of transcription and induces CYP2E1 protein through increased translation and decreased protein degradation in
primary cultured rat hepatocytes”, ASBMB 2005, San Diego, CA.

• Awarded the Certificate of “Recognition of Exceptional Academic and Research Accomplishments”, School of Medicine, Wayne State University, 2004.

• Graduated Medical School with “High Honors”, Alexandria, Egypt.

• Member of the “High Honor Society”- Alexandria University school of Medicine, Egypt.


Professional Membership:

• The American Society of Pharmacology and Experimental Therapeutics.