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Faculty & Research

• D. Randall Armant, Associate Professor of Obstetrics and Gynecology and of Anatomy and Cell Biology; Ph.D., Virginia Tech, 1980. Mammalian embryogenesis; biochemical and genetic control of trophoblast cell adhesion; regulation of in vitro preimplantation development; embryo cryopreservation.
• Dharam P. Chopra, Professor, Institute of Environmental Health Sciences; Ph.D., Newcastle (England), 1971. Oncogenes; tumor suppressor genes; growth factors; carcinogenesis; human epithelial cell culture.
• Alan A. Dombkowski, Assistant Professor, Institute of Environmental Health Sciences; Ph.D., Michigan, 2000. Bioinformatics; microarray analysis; molecular modeling and protein engineering; algorithm development.
• Ye-Shih Ho, Professor, Institute of Environmental Health Sciences; Ph.D., Carnegie Mellon, 1981. Functional analysis of antioxidant enzymes in vivo in transgenic and knockout mice.
• Thomas A. Kocarek, Associate Professor, Institute of Environmental Health Sciences; Ph.D., Ohio State, 1988. Regulation of xenobiotic metabolism.
• Lawrence H. Lash, Professor of Pharmacology; Ph.D., Emory, 1985. Biochemical mechanisms of nephrotoxicity; glutathione metabolism and transport.
• Xiangyi Lu, Associate Professor, Institute of Environmental Health Sciences; Ph.D., Yeshiva (Einstein), 1991. Molecular mechanisms underlying cilium-mediated developmental and disease processes, focusing on a cilium-associated PKD2 calcium channel in the context of polycystic kidney disease and sperm motility, primarily using Drosophila, genetic models, and cell culture.
• Raymond R. Mattingly, Associate Professor of Pharmacology; Ph.D., Virginia, 1993. Signal transduction through Ras and kinase pathways.
• Fred R. Miller, Professor, Barbara Ann Karmanos Cancer Institute; Ph.D., Wisconsin, 1976. Progression of preneoplastic breast disease; stromal-epithelial interactions; mechanisms of metastasis.
• Raymond F. Novak, Professor and Director, Institute of Environmental Health Sciences; Ph.D., Case Western Reserve, 1973. Regulation of cytochrome P-450 expression in hepatic and extrahepatic tissues and in primary cultured hepatocytes; role of metabolic disease and intracellular signaling in gene expression and cell function; microarray analysis and global gene expression profiling; role of microRNAs in regulating translation and in disease.
• John J. Reiners Jr., Professor, Institute of Environmental Health Sciences; Ph.D., Purdue, 1977. Signal transduction processes regulating apoptosis, cell-cycle progression, and dioxin receptor function.
• Barry P. Rosen, Professor and Chairman of Biochemistry and Molecular Biology; Ph.D., Connecticut, 1969. Molecular mechanisms of heavy-metal transport; pathways of uptake and detoxification of arsenic.
• Douglas M. Ruden, Associate Professor, Institute of Environmental Health Sciences; Ph.D., Harvard, 2000. Toxicogenomics of heavy metals, using Drosophila and mouse models; soma to germ-line signaling during Drosophila oogenesis; epigenetic regulation of development in Drosophila and mammalian models.
• Melissa A. Runge-Morris, Professor, Institute of Environmental Health Sciences; M.D., Michigan, 1979. Molecular regulation of sulfotransferase gene expression by hormones and xenobiotics; implications for cancer and metabolic disease progression.
• Bonnie F. Sloane, Professor and Chair of Pharmacology; Ph.D., Rutgers, 1976. Cancer biology; cysteine cathepsins and their inhibitors in tumors and their microenvironment; development of assays and 3-D organotypic model systems for real-time, live-cell imaging of proteolysis and the links between proteolytic and kinase pathways.
• Paul M. Stemmer, Associate Professor, Institute of Environmental Health Sciences; Ph.D., Michigan State, 1986. Ser/Thr phosphatase regulation; calmodulin-dependent processes; immunosuppressant and heavy-metal mechanisms of action.
• Gan Wang, Associate Professor, Institute of Environmental Health Sciences; Ph.D., Chinese Academy of Sciences, 1989. The mechanism of nucleotide excision repair (NER) in DNA damage–induced signaling process; NER deficiency and cancer development.
• Xiaoxin Susan Xu, Assistant Professor (Research), Institute of Environmental Health Sciences; Ph.D., Connecticut, 1997. DNA mismatch repair (MMR) in genetic instability and cancer development; MMR deficiency and tumor-cell drug resistance.