The Institute of Environmental Health Sciences occupies approximately 33,000 square feet of laboratory, office and vivarium space. Institute facilities include shared instrument rooms containing computer systems; spectrophotometers; electrophoresis equipment; light, fluorescence, and phase-contrast microscopes; thermocyclers; flow cytometry and protein modeling workstations; a Ciphergen mass spectrometer for protein profile analysis; an Agilent microarray scanner and bioanalyzer; as well as bioinformatics support using a variety of software programs for performing microarray experiments.

The Institute also has two darkrooms, a computer lab, several rooms dedicated to cell culture, an imaging and cytometry facility, a microarray/bioinformatics facility, a complete transgenic animal facility, and instrumentation for analysis of protein-protein interactions by Fluorescence Resonance Energy Transfer (FRET), Surface Plasmon-Resonance (SPR), and Fluorescence Polarization (FP), with additional capabilities for analysis of FRET-based biosensor signals in cells.

Other available facilities include, but are not limited to, a nucleic acid sequencing core, a laser cytometer with confocal optics, a protein mass spectrometer using a Surface Enhanced Laser Desorption Ionization (SELDI) platform, and a Biacore instrument for quantifying macromolecular interactions.

In addition, the Wayne State University Shiffman Medical Library maintains about 3,000 scientific periodicals and has more than 200,000 volumes of reference materials. The library also provides online access to several scientific and medical referencing databases.