Institute of Environmental Health Sciences

The Environmental Health Sciences Center of Excellence in Molecular and Cellular Toxicology with Human Applications at Wayne State University is funded by the National Institutes of Environmental Health Sciences and provides support for centralized resources and facilities which are shared by multiple investigators who have existing funded, peer-reviewed research projects. The EHS Center stimulates a multidisciplinary approach to joint research activities with the goal of increasing and strengthening research productivity, and generating novel ideas or approaches for research in environmental health sciences. Integration of Center activities and promotion of research in existing projects is accomplished through an administrative framework that promotes the conduct of interdisciplinary and translational research in environmental health sciences. The EHS Center structure, intellectual and technological core resources support and enhance the productivity of funded research activities. The Center structure and core resources foster interactions between established investigators and groups of established investigators and provide the contemporary technologies for pursuing high quality research on the role of environmental factors in human disease. The EHS Center thus provides an added dimension to individual research efforts, such that the overall accomplishments of the EHS Center are greater than that achieved by individual investigators and projects alone.

The EHS Center in “Molecular and Cellular Toxicology with Human Applications” is headquartered in the Institute of Environmental Health Sciences at Wayne State University. The focus of the Center is the stimulation of collaborative interdisciplinary, multidisciplinary translational research employing contemporary molecular, cellular, genomic and proteomic approaches to the study of environmental agent effects on gene expression, cell signaling and function, and human populations. Emphasis is on organochlorines/polycyclic aromatic hydrocarbon/solvents and particulates which constitute major urban/Southeastern Michigan toxicants. Disease emphasis includes asthma, hepatic dysfunction in metabolic diseases (e.g. diabetes, inflammation, dislipidemias), reproductive and neurological disorders, and cancer.

The EHS Center consists of an Administrative Core, three Research Cores, four Facility Cores, a Community Outreach and Education Program, a Pilot Project Program and an Enrichment Program (e.g. seminar series, symposium). The Research Cores consist of “Gene Regulation and Genetics”, “Cell Signaling and Function” and “Environmental Epidemiology”. The Facility cores, which consist of “Cell Culture and Gene Transfer Technologies”, “Imaging and Cytometry”, “Microarray and Bioinformatics” and “Protein Interaction and Proteomics”, are located in dedicated space with assigned personnel to support investigator funded research. An active COEP has been developed and includes science camps, competitive science awards, and dissemination of information on toxicants to the community. The Pilot Project Program contains escalating incentive funding for collaborative, interdisciplinary, multidisciplinary translational research proposals. Professional growth is stimulated through an Enrichment Program (i.e. a seminar series and an Annual Thematic Symposium). Thus, the EHS Center provides Center Members with ample opportunity and resources for collaborative interdisciplinary/multidisciplinary translational research on the role of environmental agents in disease.

The EHS Center in Molecular and Cellular Toxicology was awarded in 1994 and is headquartered in the Institute of Environmental Health Science. To learn more information regarding the center, please visit the EHS Center.





				EHS Center Headquarters
				EHS Center Headquarters
		The Environmental Health Sciences Center of Excellence in Molecular and Cellular Toxicology with Human Applications at Wayne State University is funded by the National Institutes of Environmental Health Sciences and provides support for centralized resources and facilities which are shared by multiple investigators who have existing funded, peer-reviewed research projects. The EHS Center stimulates a multidisciplinary approach to joint research activities with the goal of increasing and strengthening research productivity, and generating novel ideas or approaches for research in environmental health sciences. Integration of Center activities and promotion of research in existing projects is accomplished through an administrative framework that promotes the conduct of interdisciplinary and translational research in environmental health sciences. The EHS Center structure, intellectual and technological core resources support and enhance the productivity of funded research activities. The Center structure and core resources foster interactions between established investigators and groups of established investigators and provide the contemporary technologies for pursuing high quality research on the role of environmental factors in human disease. The EHS Center thus provides an added dimension to individual research efforts, such that the overall accomplishments of the EHS Center are greater than that achieved by individual investigators and projects alone. The EHS Center in “Molecular and Cellular Toxicology with Human Applications” is headquartered in the Institute of Environmental Health Sciences at Wayne State University. The focus of the Center is the stimulation of collaborative interdisciplinary, multidisciplinary translational research employing contemporary molecular, cellular, genomic and proteomic approaches to the study of environmental agent effects on gene expression, cell signaling and function, and human populations. Emphasis is on organochlorines/polycyclic aromatic hydrocarbon/solvents and particulates which constitute major urban/Southeastern Michigan toxicants. Disease emphasis includes asthma, hepatic dysfunction in metabolic diseases (e.g. diabetes, inflammation, dislipidemias), reproductive and neurological disorders, and cancer. The EHS Center consists of an Administrative Core, three Research Cores, four Facility Cores, a Community Outreach and Education Program, a Pilot Project Program and an Enrichment Program (e.g. seminar series, symposium). The Research Cores consist of “Gene Regulation and Genetics”, “Cell Signaling and Function” and “Environmental Epidemiology”. The Facility cores, which consist of “Cell Culture and Gene Transfer Technologies”, “Imaging and Cytometry”, “Microarray and Bioinformatics” and “Protein Interaction and Proteomics”, are located in dedicated space with assigned personnel to support investigator funded research. An active COEP has been developed and includes science camps, competitive science awards, and dissemination of information on toxicants to the community. The Pilot Project Program contains escalating incentive funding for collaborative, interdisciplinary, multidisciplinary translational research proposals. Professional growth is stimulated through an Enrichment Program (i.e. a seminar series and an Annual Thematic Symposium). Thus, the EHS Center provides Center Members with ample opportunity and resources for collaborative interdisciplinary/multidisciplinary translational research on the role of environmental agents in disease. The EHS Center in Molecular and Cellular Toxicology was awarded in 1994 and is headquartered in the Institute of Environmental Health Science. To learn more information regarding the center, please visit the EHS Center.